Continuous Hypoxia Reduces Retinal Ganglion Cell Degeneration in a Mouse Model of Mitochondrial Optic Neuropathy

PURPOSE: To test whether continuous hypoxia is neuroprotective to retinal ganglion cells (RGCs) in a mouse model of mitochondrial optic neuropathy. METHODS: RGC degeneration was assessed in genetically modified mice in which the floxed gene for the complex I subunit NDUFS4 is deleted from RGCs using...

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Detalles Bibliográficos
Autores principales: Warwick, Alexander M., Bomze, Howard M., Wang, Luyu, Klingeborn, Mikael, Hao, Ying, Stinnett, Sandra S., Gospe III, Sidney M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2022
Materias:
Retinal Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769749/
https://www.ncbi.nlm.nih.gov/pubmed/36538003
http://dx.doi.org/10.1167/iovs.63.13.21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769749/
https://www.ncbi.nlm.nih.gov/pubmed/36538003
http://dx.doi.org/10.1167/iovs.63.13.21

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