Fibroblasts repair blood-brain barrier damage and hemorrhagic brain injury via TIMP2

The function of fibroblasts in intracerebral hemorrhage (ICH) remains elusive. By targeting Col1α1, a fibroblast-specific marker, we generate mice with ablated Col1α1(+) fibroblasts. These mutants show exacerbated blood-brain barrier (BBB) damage, enlarged injury volume, and worse neurological funct...

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Detalles Bibliográficos
Autores principales: Xu, Lingling, Nirwane, Abhijit, Xu, Ting, Kang, Minkyung, Devasani, Karan, Yao, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769996/
https://www.ncbi.nlm.nih.gov/pubmed/36417884
http://dx.doi.org/10.1016/j.celrep.2022.111709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769996/
https://www.ncbi.nlm.nih.gov/pubmed/36417884
http://dx.doi.org/10.1016/j.celrep.2022.111709

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