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FUCOIDANS ARE NOVEL SENOTHERAPEUTICS THAT ENHANCE SIRT6 AND DNA REPAIR ACTIVITY
With age, senescent cells accumulate in various tissues where they contribute to loss of tissue homeostasis, aging, and age-related diseases through their inflammatory senescence-associated secretory phenotypes (SASPs). Senotherapeutics able to selectively eliminate senescent cells, termed senolytic...
Autores principales: | Zhang, Lei, Hughes, Brian, Tombline, Gregory, Angelini, Luise, Yousefzadeh, Matt, Gorbunova, Vera, Niedernhofer, Laura, Robbins, Paul |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9770113/ http://dx.doi.org/10.1093/geroni/igac059.522 |
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