Nanoparticle delivery of CD40 siRNA suppresses alloimmune responses by inhibiting activation and differentiation of DCs and macrophages

CD40 is an important costimulatory molecule expressed on antigen-presenting cells (APCs) and plays a critical role for APC activation, offering a promising therapeutic target for preventing allograft rejection. Here, we developed a biodegradable nanoparticle small interfering RNA delivery system (si...

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Detalles Bibliográficos
Autores principales: Wang, Jialiang, Mao, Kuirong, Cong, Xiuxiu, Tan, Huizhu, Wu, Chenxi, Hu, Zheng, Yang, Yong-Guang, Sun, Tianmeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9770959/
https://www.ncbi.nlm.nih.gov/pubmed/36542700
http://dx.doi.org/10.1126/sciadv.abq3699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9770959/
https://www.ncbi.nlm.nih.gov/pubmed/36542700
http://dx.doi.org/10.1126/sciadv.abq3699

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