GABA signaling triggered by TMC-1/Tmc delays neuronal aging by inhibiting the PKC pathway in C. elegans

Aging causes functional decline and degeneration of neurons and is a major risk factor of neurodegenerative diseases. To investigate the molecular mechanisms underlying neuronal aging, we developed a new pipeline for neuronal proteomic profiling in young and aged animals. While the overall translati...

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Detalles Bibliográficos
Autores principales: Wu, Jieyu, Wang, Liuyang, Ervin, John F., Wang, Shih-Hsiu J., Soderblom, Erik, Ko, Dennis, Yan, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9770988/
https://www.ncbi.nlm.nih.gov/pubmed/36542715
http://dx.doi.org/10.1126/sciadv.adc9236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9770988/
https://www.ncbi.nlm.nih.gov/pubmed/36542715
http://dx.doi.org/10.1126/sciadv.adc9236

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