Gallbladder adenocarcinomas undergo subclonal diversification and selection from precancerous lesions to metastatic tumors

We aimed to elucidate the evolutionary trajectories of gallbladder adenocarcinoma (GBAC) using multi-regional and longitudinal tumor samples. Using whole-exome sequencing data, we constructed phylogenetic trees in each patient and analyzed mutational signatures. A total of 11 patients including 2 ra...

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Detalles Bibliográficos
Autores principales: Kang, Minsu, Na, Hee Young, Ahn, Soomin, Kim, Ji-Won, Lee, Sejoon, Ahn, Soyeon, Lee, Ju Hyun, Youk, Jeonghwan, Kim, Haesook T, Kim, Kui-Jin, Suh, Koung Jin, Lee, Jun Suh, Kim, Se Hyun, Kim, Jin Won, Kim, Yu Jung, Lee, Keun-Wook, Yoon, Yoo-Seok, Kim, Jee Hyun, Chung, Jin-Haeng, Han, Ho-Seong, Lee, Jong Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771369/
https://www.ncbi.nlm.nih.gov/pubmed/36476508
http://dx.doi.org/10.7554/eLife.78636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771369/
https://www.ncbi.nlm.nih.gov/pubmed/36476508
http://dx.doi.org/10.7554/eLife.78636

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