Tenuous transcriptional threshold of human sex determination. II. SRY exploits water-mediated clamp at the edge of ambiguity

Y-encoded transcription factor SRY initiates male differentiation in therian mammals. This factor contains a high-mobility-group (HMG) box, which mediates sequence-specific DNA binding with sharp DNA bending. A companion article in this issue described sex-reversal mutations at box position 72 (resi...

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Detalles Bibliográficos
Autores principales: Racca, Joseph D., Chatterjee, Deepak, Chen, Yen-Shan, Rai, Ratan K., Yang, Yanwu, Georgiadis, Millie M., Haas, Elisha, Weiss, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771472/
https://www.ncbi.nlm.nih.gov/pubmed/36568077
http://dx.doi.org/10.3389/fendo.2022.1029177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771472/
https://www.ncbi.nlm.nih.gov/pubmed/36568077
http://dx.doi.org/10.3389/fendo.2022.1029177

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