SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia

Histone methyltransferase SETD1A is critical for acute myeloid leukemia (AML) cell survival, but the molecular mechanism driving SETD1A gene regulation remains elusive. To delineate the role of SETD1A, we utilize a protein degrader technology to induce rapid SETD1A degradation in AML cell lines. SET...

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Detalles Bibliográficos
Autores principales: Hoshii, Takayuki, Perlee, Sarah, Kikuchi, Sota, Rahmutulla, Bahityar, Fukuyo, Masaki, Masuda, Takeshi, Ohtsuki, Sumio, Soga, Tomoyoshi, Nabet, Behnam, Kaneda, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771694/
https://www.ncbi.nlm.nih.gov/pubmed/36450243
http://dx.doi.org/10.1016/j.celrep.2022.111727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771694/
https://www.ncbi.nlm.nih.gov/pubmed/36450243
http://dx.doi.org/10.1016/j.celrep.2022.111727

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