Diptoindonesin G is a middle domain HSP90 modulator for cancer treatment

HSP90 inhibitors can target many oncoproteins simultaneously, but none have made it through clinical trials due to dose-limiting toxicity and induction of heat shock response, leading to clinical resistance. We identified diptoindonesin G (dip G) as an HSP90 modulator that can promote degradation of...

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Detalles Bibliográficos
Autores principales: Donahue, Kristine, Xie, Haibo, Li, Miyang, Gao, Ang, Ma, Min, Wang, Yidan, Tipton, Rose, Semanik, Nicole, Primeau, Tina, Li, Shunqiang, Li, Lingjun, Tang, Weiping, Xu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771721/
https://www.ncbi.nlm.nih.gov/pubmed/36395883
http://dx.doi.org/10.1016/j.jbc.2022.102700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771721/
https://www.ncbi.nlm.nih.gov/pubmed/36395883
http://dx.doi.org/10.1016/j.jbc.2022.102700

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