Lipoxin A4 attenuates MSU-crystal-induced NLRP3 inflammasome activation through suppressing Nrf2 thereby increasing TXNRD2

Gout is a common inflammatory disease. The activation of NLRP3 inflammasome induced by monosodium urate (MSU) crystals has a critical role in gout, and its prevention is beneficial for patients. Lipoxin A4 (LXA4) is an endogenous lipoxygenase-derived eicosanoid mediator with powerful anti-inflammato...

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Detalles Bibliográficos
Autores principales: Zhou, You, Chen, Yongjun, Zhong, Xiaowu, Xia, Hongtao, Zhao, Mingcai, Zhao, Mengyuan, Xu, Lei, Guo, Xiaolan, You, Chong-Ge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772058/
https://www.ncbi.nlm.nih.gov/pubmed/36569930
http://dx.doi.org/10.3389/fimmu.2022.1060441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772058/
https://www.ncbi.nlm.nih.gov/pubmed/36569930
http://dx.doi.org/10.3389/fimmu.2022.1060441

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