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Functional investigation of SLC1A2 variants associated with epilepsy
Epilepsy is a common neurological disorder and glutamate excitotoxicity plays a key role in epileptic pathogenesis. Astrocytic glutamate transporter GLT-1 is responsible for preventing excitotoxicity via clearing extracellular accumulated glutamate. Previously, three variants (G82R, L85P, and P289R)...
Autores principales: | Qu, Qi, Zhang, Wenlong, Wang, Ji, Mai, Dongmei, Ren, Siqiang, Qu, Shaogang, Zhang, Yunlong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772344/ https://www.ncbi.nlm.nih.gov/pubmed/36543780 http://dx.doi.org/10.1038/s41419-022-05457-6 |
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