Diversity in Cortical Thymic Epithelial Cells Occurs through Loss of a Foxn1-Dependent Gene Signature Driven by Stage-Specific Thymocyte Cross-Talk

In the thymus, cortical thymic epithelial cells (cTECs) and medullary thymic epithelial cells support αβT cell development from lymphoid progenitors. For cTECs, expression of a specialized gene signature that includes Cxcl12, Dll4, and Psmb11 enables the cortex to support T lineage commitment and th...

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Detalles Bibliográficos
Autores principales: White, Andrea J., Parnell, Sonia M., Handel, Adam, Maio, Stefano, Bacon, Andrea, Cosway, Emilie J., Lucas, Beth, James, Kieran D., Cowan, Jennifer E., Jenkinson, William E., Hollander, Georg A., Anderson, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2023
Materias:
Immune System Development
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772400/
https://www.ncbi.nlm.nih.gov/pubmed/36427001
http://dx.doi.org/10.4049/jimmunol.2200609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772400/
https://www.ncbi.nlm.nih.gov/pubmed/36427001
http://dx.doi.org/10.4049/jimmunol.2200609

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