Immunoglobulin VDJ repertoires reveal hallmarks of germinal centers in unique cell clusters isolated from zebrafish (Danio rerio) lymphoid tissues

DNA mutagenesis during antibody affinity maturation has potentially oncogenic or autoimmune outcomes if not tightly controlled as it is in mammalian germinal centers. Cold blooded vertebrates lack germinal centers, yet have a functional Ig gene mutator enzyme, Aicda. In fish there are clusters of Ai...

Descripción completa

Detalles Bibliográficos
Autores principales: Waly, Doaa, Muthupandian, Aradana, Fan, Chia-Wei, Anzinger, Harrison, Magor, Brad G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772432/
https://www.ncbi.nlm.nih.gov/pubmed/36569890
http://dx.doi.org/10.3389/fimmu.2022.1058877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772432/
https://www.ncbi.nlm.nih.gov/pubmed/36569890
http://dx.doi.org/10.3389/fimmu.2022.1058877

Ejemplares similares