Joint population pharmacokinetic modeling of venlafaxine and O-desmethyl venlafaxine in healthy volunteers and patients to evaluate the impact of morbidity and concomitant medication

Introduction: Venlafaxine (VEN) is a widely used dual selective serotonin/noradrenaline reuptake inhibitor indicated for depression and anxiety. It undergoes first-pass metabolism to its active metabolite, O-desmethyl venlafaxine (ODV). The aim of the present study was to develop a joint population...

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Detalles Bibliográficos
Autores principales: Wang, Zhanzhang, Li, Lu, Huang, Shanqing, Wang, Xipei, Liu, Shujing, Li, Xiaolin, Kong, Wan, Ni, Xiaojia, Zhang, Ming, Huang, Shanshan, Tan, Yaqian, Wen, Yuguan, Shang, Dewei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772442/
https://www.ncbi.nlm.nih.gov/pubmed/36569310
http://dx.doi.org/10.3389/fphar.2022.978202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772442/
https://www.ncbi.nlm.nih.gov/pubmed/36569310
http://dx.doi.org/10.3389/fphar.2022.978202

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