Cargando…

Retinal pigment epithelium extracellular vesicles are potent inducers of age‐related macular degeneration disease phenotype in the outer retina

Age‐related macular degeneration (AMD) is a leading cause of blindness. Vision loss is caused by the retinal pigment epithelium (RPE) and photoreceptors atrophy and/or retinal and choroidal angiogenesis. Here we use AMD patient‐specific RPE cells with the Complement Factor H Y402H high‐risk polymorp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kurzawa‐Akanbi, Marzena, Whitfield, Phillip, Burté, Florence, Bertelli, Pietro Maria, Pathak, Varun, Doherty, Mary, Hilgen, Birthe, Gliaudelytė, Lina, Platt, Mark, Queen, Rachel, Coxhead, Jonathan, Porter, Andrew, Öberg, Maria, Fabrikova, Daniela, Davey, Tracey, Beh, Chia Shyan, Georgiou, Maria, Collin, Joseph, Boczonadi, Veronika, Härtlova, Anetta, Taggart, Michael, Al‐Aama, Jumana, Korolchuk, Viktor I, Morris, Christopher M, Guduric‐Fuchs, Jasenka, Steel, David H, Medina, Reinhold J, Armstrong, Lyle, Lako, Majlinda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772497/ https://www.ncbi.nlm.nih.gov/pubmed/36544284 http://dx.doi.org/10.1002/jev2.12295

Ejemplares similares

Complement modulation reverses pathology in Y402H‐retinal pigment epithelium cell model of age‐related macular degeneration by restoring lysosomal function
por: Cerniauskas, Edvinas, et al.
Publicado: (2020)

pRB-Depleted Pluripotent Stem Cell Retinal Organoids Recapitulate Cell State Transitions of Retinoblastoma Development and Suggest an Important Role for pRB in Retinal Cell Differentiation
por: Rozanska, Agata, et al.
Publicado: (2022)

Lung macrophages utilize unique cathepsin K–dependent phagosomal machinery to degrade intracellular collagen
por: Fabrik, Ivo, et al.
Publicado: (2023)

Room temperature shipment does not affect the biological activity of pluripotent stem cell-derived retinal organoids
por: Georgiou, Maria, et al.
Publicado: (2020)

Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders
por: Kurzawa-Akanbi, Marzena, et al.
Publicado: (2021)

The Role of Nerve Growth Factor in Maintaining Proliferative Capacity, Colony‐Forming Efficiency, and the Limbal Stem Cell Phenotype
por: Kolli, Sai, et al.
Publicado: (2018)

Deconstructing Retinal Organoids: Single Cell RNA‐Seq Reveals the Cellular Components of Human Pluripotent Stem Cell‐Derived Retina
por: Collin, Joseph, et al.
Publicado: (2019)

Generating inner ear organoids containing putative cochlear hair cells from human pluripotent stem cells
por: Jeong, Minjin, et al.
Publicado: (2018)

Systematic Comparison of Retinal Organoid Differentiation from Human Pluripotent Stem Cells Reveals Stage Specific, Cell Line, and Methodological Differences
por: Mellough, Carla B., et al.
Publicado: (2019)

Human iPSC differentiation to retinal organoids in response to IGF1 and BMP4 activation is line‐ and method‐dependent
por: Chichagova, Valeria, et al.
Publicado: (2019)

Pre-mRNA Processing Factors and Retinitis Pigmentosa: RNA Splicing and Beyond
por: Yang, Chunbo, et al.
Publicado: (2021)

Somatic mtDNA variation is an important component of Parkinson's disease
por: Coxhead, Jonathan, et al.
Publicado: (2016)

Co-expression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface
por: Collin, Joseph, et al.
Publicado: (2021)

Single-cell RNA sequencing reveals transcriptional changes of human choroidal and retinal pigment epithelium cells during fetal development, in healthy adult and intermediate age-related macular degeneration
por: Collin, Joseph, et al.
Publicado: (2023)

The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages
por: Zhu, Lili, et al.
Publicado: (2016)

Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient‐induced pluripotent stem cell‐derived retinal pigment epithelium cells
por: Georgiou, Maria, et al.
Publicado: (2022)

Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: A Comprehensive Validation Using Drugs and Compounds Affecting the Retina
por: Dorgau, Birthe, et al.
Publicado: (2022)

Incorporating microglia‐like cells in human induced pluripotent stem cell‐derived retinal organoids
por: Chichagova, Valeria, et al.
Publicado: (2023)

Long term high glucose exposure induces premature senescence in retinal endothelial cells
por: Bertelli, Pietro Maria, et al.
Publicado: (2022)

The E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to bacterial infection
por: Bilkei‐Gorzo, Orsolya, et al.
Publicado: (2022)

Using Zinc Finger Nuclease Technology to Generate CRX‐Reporter Human Embryonic Stem Cells as a Tool to Identify and Study the Emergence of Photoreceptors Precursors During Pluripotent Stem Cell Differentiation
por: Collin, Joseph, et al.
Publicado: (2015)

Specialty Grand Challenge – Genetic Disorders
por: Al-Aama, Jumana Y.
Publicado: (2013)

Balancing Work and Life: A Conversation with Fiona Watt
por: Lako, Majlinda, et al.
Publicado: (2009)

Editorial: Methods and advances in induced pluripotent stem cells—ophthalmology
por: Armstrong, Lyle, et al.
Publicado: (2023)

Retinal organoids provide unique insights into molecular signatures of inherited retinal disease throughout retinogenesis
por: Watson, Avril, et al.
Publicado: (2022)

Human‐Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient‐Dependent Efficiency
por: Hallam, Dean, et al.
Publicado: (2018)

Cellular regeneration strategies for macular degeneration: past, present and future
por: Chichagova, Valeria, et al.
Publicado: (2018)

Developing a simple method to enhance the generation of cone and rod photoreceptors in pluripotent stem cell‐derived retinal organoids
por: Zerti, Darin, et al.
Publicado: (2019)

How to build a human
por: Mellough, Carla B, et al.
Publicado: (2016)

Macrophages and scavenger receptors in obesity‐associated non‐alcoholic liver fatty disease (NAFLD)
por: Kragh Petersen, Sine, et al.
Publicado: (2020)

Law, Ethics, Religion, and Clinical Translation in the 21(st) Century – A Discussion with Pete Coffey
por: Lako, Majlinda, et al.
Publicado: (2010)

Stem Cells, Inflammation, and Fibrosis
por: Volarevic, Vladislav, et al.
Publicado: (2016)

RPE and neuronal differentiation of allotransplantated porcine ciliary epithelium-derived cells
por: Guduric-Fuchs, Jasenka, et al.
Publicado: (2011)

Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation
por: Dorgau, Birthe, et al.
Publicado: (2018)

Law, Ethics, Religion, and Clinical Translation in the 21st Century—A Discussion with Andrew Webster
por: Lako, Majlinda, et al.
Publicado: (2010)

Referral Patterns of Patients with Limbal Stem Cell Deficiency to a Specialized Tertiary Center in the United Kingdom
por: Cartes, Cristian, et al.
Publicado: (2021)

CRX Expression in Pluripotent Stem Cell‐Derived Photoreceptors Marks a Transplantable Subpopulation of Early Cones
por: Collin, Joseph, et al.
Publicado: (2019)

Prediction of microRNAs affecting mRNA expression during retinal development
por: Arora, Amit, et al.
Publicado: (2010)

Law, Ethics, Religion, and Clinical Translation in the 21st Century—A Discussion with Derek Hei
por: Daher, Susan Rainey, et al.
Publicado: (2010)

Genetic Basis of Inherited Macular Dystrophies and Implications for Stem Cell Therapy
por: Mellough, Carla B, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_blvq34gfc8f1fvmd1kugkk49iq