Modeling resistance of colorectal peritoneal metastases to immune checkpoint blockade in humanized mice

BACKGROUND: The immunogenic nature of metastatic colorectal cancer (CRC) with high microsatellite instability (MSI-H) underlies their responsiveness to immune checkpoint blockade (ICB). However, resistance to ICB is commonly observed, and is associated with the presence of peritoneal-metastases and...

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Detalles Bibliográficos
Autores principales: Küçükköse, Emre, Heesters, Balthasar A, Villaudy, Julien, Verheem, André, Cercel, Madalina, van Hal, Susan, Boj, Sylvia F, Borel Rinkes, Inne H M, Punt, Cornelis J A, Roodhart, Jeanine M L, Laoukili, Jamila, Koopman, Miriam, Spits, Hergen, Kranenburg, Onno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772695/
https://www.ncbi.nlm.nih.gov/pubmed/36543378
http://dx.doi.org/10.1136/jitc-2022-005345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772695/
https://www.ncbi.nlm.nih.gov/pubmed/36543378
http://dx.doi.org/10.1136/jitc-2022-005345

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