The Shank3(Venus/Venus) knock in mouse enables isoform-specific functional studies of Shank3a

BACKGROUND: Shank3 is a scaffolding protein essential for the organization and function of the glutamatergic postsynapse. Monogenic mutations in SHANK3 gene are among the leading genetic causes of Autism Spectrum Disorders (ASD). The multiplicity of Shank3 isoforms seems to generate as much function...

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Detalles Bibliográficos
Autores principales: Bouquier, Nathalie, Sakkaki, Sophie, Raynaud, Fabrice, Hemonnot-Girard, Anne-Laure, Seube, Vincent, Compan, Vincent, Bertaso, Federica, Perroy, Julie, Moutin, Enora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773256/
https://www.ncbi.nlm.nih.gov/pubmed/36570823
http://dx.doi.org/10.3389/fnins.2022.1081010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773256/
https://www.ncbi.nlm.nih.gov/pubmed/36570823
http://dx.doi.org/10.3389/fnins.2022.1081010

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