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The Shank3(Venus/Venus) knock in mouse enables isoform-specific functional studies of Shank3a
BACKGROUND: Shank3 is a scaffolding protein essential for the organization and function of the glutamatergic postsynapse. Monogenic mutations in SHANK3 gene are among the leading genetic causes of Autism Spectrum Disorders (ASD). The multiplicity of Shank3 isoforms seems to generate as much function...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773256/ https://www.ncbi.nlm.nih.gov/pubmed/36570823 http://dx.doi.org/10.3389/fnins.2022.1081010 |