Interference with pathways activated by topoisomerase inhibition alters the surface expression of PD-L1 and MHC I in colon cancer cells

Topoisomerase inhibitors are clinically used to treat various cancer types, including colorectal cancer. These drugs also activate signaling pathways that modulate cell survival and immune cell functions. Immunotherapy is promising for certain tumors, including microsatellite instable colorectal can...

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Detalles Bibliográficos
Autores principales: Hassan, Mohamed, Trung, Vu, Bedi, Deepa, Shaddox, Sage, Gunturu, Dilip, Yates, Clayton, Datta, Pran, Samuel, Temesgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773314/
https://www.ncbi.nlm.nih.gov/pubmed/36589674
http://dx.doi.org/10.3892/ol.2022.13628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773314/
https://www.ncbi.nlm.nih.gov/pubmed/36589674
http://dx.doi.org/10.3892/ol.2022.13628

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