Computational insights for predicting the binding and selectivity of peptidomimetic plasmepsin IV inhibitors against cathepsin D

Plasmepsins (Plms) are aspartic proteases involved in the degradation of human hemoglobin by P. falciparum and are essential for the survival and growth of the parasite. Therefore, Plm enzymes are reported as an important antimalarial drug target. Herein, we have applied molecular docking, molecular...

Descripción completa

Detalles Bibliográficos
Autores principales: Martins, Lucas Sousa, Kruger, Hendrik Gerhardus, Naicker, Tricia, Alves, Cláudio Nahum, Lameira, Jerônimo, Araújo Silva, José Rogério
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773328/
https://www.ncbi.nlm.nih.gov/pubmed/36605626
http://dx.doi.org/10.1039/d2ra06246a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773328/
https://www.ncbi.nlm.nih.gov/pubmed/36605626
http://dx.doi.org/10.1039/d2ra06246a

Ejemplares similares