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Mechanisms of PARP1 inhibitor resistance and their implications for cancer treatment
The discovery of synthetic lethality as a result of the combined loss of PARP1 and BRCA has revolutionized the treatment of DNA repair-deficient cancers. With the development of PARP inhibitors, patients displaying germline or somatic mutations in BRCA1 or BRCA2 were presented with a novel therapeut...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773381/ https://www.ncbi.nlm.nih.gov/pubmed/36568963 http://dx.doi.org/10.1093/narcan/zcac042 |