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Neuroendocrine hormone status and diuretic response to atrial natriuretic peptide in patients with acute heart failure

AIMS: Given the various effects of sacubitril/valsartan in heart failure, a deeper understanding of atrial natriuretic peptide (ANP) actions is warranted. Natriuresis is a fundamental action of ANP in acute heart failure (AHF), whereas the diuretic effect of ANP is different in each patient accordin...

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Autores principales: Matsumoto, Shingo, Nakamura, Norihito, Konishi, Masaaki, Shibata, Atsushi, Kida, Keisuke, Ishii, Shunsuke, Ikeda, Takanori, Ikari, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773655/
https://www.ncbi.nlm.nih.gov/pubmed/36043451
http://dx.doi.org/10.1002/ehf2.14083
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author Matsumoto, Shingo
Nakamura, Norihito
Konishi, Masaaki
Shibata, Atsushi
Kida, Keisuke
Ishii, Shunsuke
Ikeda, Takanori
Ikari, Yuji
author_facet Matsumoto, Shingo
Nakamura, Norihito
Konishi, Masaaki
Shibata, Atsushi
Kida, Keisuke
Ishii, Shunsuke
Ikeda, Takanori
Ikari, Yuji
author_sort Matsumoto, Shingo
collection PubMed
description AIMS: Given the various effects of sacubitril/valsartan in heart failure, a deeper understanding of atrial natriuretic peptide (ANP) actions is warranted. Natriuresis is a fundamental action of ANP in acute heart failure (AHF), whereas the diuretic effect of ANP is different in each patient according to the diversity of renal response to ANP, which is affected by baseline plasma ANP status and deficiency of circulating ANP. Meanwhile, associations between other neuroendocrine hormones and the diuretic response to ANP are unclear. This study investigated the impact of pivotal neuroendocrine hormones on the diuretic effects of exogenous ANP, carperitide. METHODS AND RESULTS: Plasma ANP, renin, aldosterone, and vasopressin levels and the diuretic effect of 0.0125 μg/kg/min of carperitide alone for the first 6 h were prospectively evaluated in 75 patients with AHF. Lower ANP levels were significantly associated with a greater diuretic response to exogenous ANP (r = −0.35, P = 0.002). Additionally, higher vasopressin levels were significantly related to the poor diuretic effects of exogenous ANP (r = −0.54, P < 0.001). Plasma ANP and vasopressin concentrations were not significantly correlated (r = 0.19, P = 0.10). Baseline systolic blood pressure, renal function, and prior use of loop diuretics did not predict the diuretic response to exogenous ANP, whereas vasopressin levels independently predicted a diuretic response to exogenous ANP (P < 0.001), as well as lower plasma ANP levels (P = 0.027). CONCLUSIONS: Vasopressin status was significantly associated with the diuretic response to exogenous ANP in AHF, independent of plasma ANP status. The results may provide a better understanding of the actions of sacubitril/valsartan.
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spelling pubmed-97736552022-12-23 Neuroendocrine hormone status and diuretic response to atrial natriuretic peptide in patients with acute heart failure Matsumoto, Shingo Nakamura, Norihito Konishi, Masaaki Shibata, Atsushi Kida, Keisuke Ishii, Shunsuke Ikeda, Takanori Ikari, Yuji ESC Heart Fail Original Articles AIMS: Given the various effects of sacubitril/valsartan in heart failure, a deeper understanding of atrial natriuretic peptide (ANP) actions is warranted. Natriuresis is a fundamental action of ANP in acute heart failure (AHF), whereas the diuretic effect of ANP is different in each patient according to the diversity of renal response to ANP, which is affected by baseline plasma ANP status and deficiency of circulating ANP. Meanwhile, associations between other neuroendocrine hormones and the diuretic response to ANP are unclear. This study investigated the impact of pivotal neuroendocrine hormones on the diuretic effects of exogenous ANP, carperitide. METHODS AND RESULTS: Plasma ANP, renin, aldosterone, and vasopressin levels and the diuretic effect of 0.0125 μg/kg/min of carperitide alone for the first 6 h were prospectively evaluated in 75 patients with AHF. Lower ANP levels were significantly associated with a greater diuretic response to exogenous ANP (r = −0.35, P = 0.002). Additionally, higher vasopressin levels were significantly related to the poor diuretic effects of exogenous ANP (r = −0.54, P < 0.001). Plasma ANP and vasopressin concentrations were not significantly correlated (r = 0.19, P = 0.10). Baseline systolic blood pressure, renal function, and prior use of loop diuretics did not predict the diuretic response to exogenous ANP, whereas vasopressin levels independently predicted a diuretic response to exogenous ANP (P < 0.001), as well as lower plasma ANP levels (P = 0.027). CONCLUSIONS: Vasopressin status was significantly associated with the diuretic response to exogenous ANP in AHF, independent of plasma ANP status. The results may provide a better understanding of the actions of sacubitril/valsartan. John Wiley and Sons Inc. 2022-08-31 /pmc/articles/PMC9773655/ /pubmed/36043451 http://dx.doi.org/10.1002/ehf2.14083 Text en © 2022 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Matsumoto, Shingo
Nakamura, Norihito
Konishi, Masaaki
Shibata, Atsushi
Kida, Keisuke
Ishii, Shunsuke
Ikeda, Takanori
Ikari, Yuji
Neuroendocrine hormone status and diuretic response to atrial natriuretic peptide in patients with acute heart failure
title Neuroendocrine hormone status and diuretic response to atrial natriuretic peptide in patients with acute heart failure
title_full Neuroendocrine hormone status and diuretic response to atrial natriuretic peptide in patients with acute heart failure
title_fullStr Neuroendocrine hormone status and diuretic response to atrial natriuretic peptide in patients with acute heart failure
title_full_unstemmed Neuroendocrine hormone status and diuretic response to atrial natriuretic peptide in patients with acute heart failure
title_short Neuroendocrine hormone status and diuretic response to atrial natriuretic peptide in patients with acute heart failure
title_sort neuroendocrine hormone status and diuretic response to atrial natriuretic peptide in patients with acute heart failure
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773655/
https://www.ncbi.nlm.nih.gov/pubmed/36043451
http://dx.doi.org/10.1002/ehf2.14083
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