Cargando…

Effect of the Mediterranean diet and probiotic supplementation in the management of mild cognitive impairment: Rationale, methods, and baseline characteristics

INTRODUCTION: Mild cognitive impairment (MCI) can progress to Alzheimer’s disease (AD). When MCI is not properly controlled, the speed of deterioration can dramatically increase. Reduction of oxidative stress/inflammation and the modulation of the gut-brain axis could be new potential therapeutic ta...

Descripción completa

Detalles Bibliográficos
Autores principales: Cardelo, Magdalena P., Corina, Andreea, Leon-Acuña, Ana, Quintana-Navarro, Gracia M., Alcala-Diaz, Juan F., Rangel-Zuñiga, Oriol Alberto, Camargo, Antonio, Conde-Gavilan, Cristina, Carmona-Medialdea, Claudia, Vallejo-Casas, Juan A., Carmona-Asenjo, Elvira, Ochoa-Sepulveda, Juan J., Aguera-Morales, Eduardo, Delgado-Lista, Javier, Katsiki, Niki, Lopez-Miranda, José, Perez-Jimenez, Francisco, Yubero-Serrano, Elena M., Perez-Martínez, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773830/
https://www.ncbi.nlm.nih.gov/pubmed/36570150
http://dx.doi.org/10.3389/fnut.2022.1037842
_version_ 1784855276172607488
author Cardelo, Magdalena P.
Corina, Andreea
Leon-Acuña, Ana
Quintana-Navarro, Gracia M.
Alcala-Diaz, Juan F.
Rangel-Zuñiga, Oriol Alberto
Camargo, Antonio
Conde-Gavilan, Cristina
Carmona-Medialdea, Claudia
Vallejo-Casas, Juan A.
Carmona-Asenjo, Elvira
Ochoa-Sepulveda, Juan J.
Aguera-Morales, Eduardo
Delgado-Lista, Javier
Katsiki, Niki
Lopez-Miranda, José
Perez-Jimenez, Francisco
Yubero-Serrano, Elena M.
Perez-Martínez, Pablo
author_facet Cardelo, Magdalena P.
Corina, Andreea
Leon-Acuña, Ana
Quintana-Navarro, Gracia M.
Alcala-Diaz, Juan F.
Rangel-Zuñiga, Oriol Alberto
Camargo, Antonio
Conde-Gavilan, Cristina
Carmona-Medialdea, Claudia
Vallejo-Casas, Juan A.
Carmona-Asenjo, Elvira
Ochoa-Sepulveda, Juan J.
Aguera-Morales, Eduardo
Delgado-Lista, Javier
Katsiki, Niki
Lopez-Miranda, José
Perez-Jimenez, Francisco
Yubero-Serrano, Elena M.
Perez-Martínez, Pablo
author_sort Cardelo, Magdalena P.
collection PubMed
description INTRODUCTION: Mild cognitive impairment (MCI) can progress to Alzheimer’s disease (AD). When MCI is not properly controlled, the speed of deterioration can dramatically increase. Reduction of oxidative stress/inflammation and the modulation of the gut-brain axis could be new potential therapeutic targets for the prevention and treatment of AD. Consumption of specific nutrients, diets and probiotic supplementation have been evaluated for neurodegenerative disorders. We focus on a detailed description of the study methods and baseline characteristics of a clinical trial aiming to evaluate the efficacy of a combined nutritional intervention, i.e., a Mediterranean diet with probiotics, on cognitive capacity in a population with MCI. METHODS: In this randomized, latin-square crossover, double-blind, and controlled dietary intervention trial (clinicaltrials.gov NCT05029765), 47 MCI patients were randomized to consume three dietary interventions for 24-weeks each: (1) A Mediterranean diet supplemented with probiotics (10(9) colony-forming units of Lactobacillus rhamnosus and Bifidobacterium longum); (2) A Mediterranean diet + placebo; and (3) A Healthy diet according to the World Health Organization (WHO) recommendations. Participants will be evaluated before and after each of the three intervention periods (each 24-weeks, with a total of 72-weeks) for adherence to the assigned diet, blood tests, cognitive performance, gut microbiota analysis and functional neuroimaging studies. RESULTS: Fifty patients, ≥60 years-old and diagnosed with MCI, underwent randomization. A total of 47 patients completed follow-up dietary interventions (57.4% males), with a good glycemic control (HbA1c 5.8 ± 0.1%, fasting glucose and insulin 99.7 ± 3.3 mg/dL and 10.4 ± 0.9 mU/L, respectively), elevated systolic blood pressure (136.9 ± 2.1 mmHg) and increased degree of inflammation (high-sensitivity C-reactive protein, 8.8 ± 0.9 mg/dL). Baseline adherence to the Mediterranean diet was medium (7.5 ± 0.3 points on the score that ranged from 0 to 14 points). CONCLUSION: The results of this clinical study would provide more evidence on the need for dietary therapeutic strategies, for clinical and individual practice, in the management of MCI patients to reduce the risk of AD development. Targeting lifestyle modifications in high-risk populations could prevent substantial cases of cognitive decline. CLINICAL TRIAL REGISTRATION: [ClinicalTrials.gov], identifier [NCT05029765].
format Online
Article
Text
id pubmed-9773830
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-97738302022-12-23 Effect of the Mediterranean diet and probiotic supplementation in the management of mild cognitive impairment: Rationale, methods, and baseline characteristics Cardelo, Magdalena P. Corina, Andreea Leon-Acuña, Ana Quintana-Navarro, Gracia M. Alcala-Diaz, Juan F. Rangel-Zuñiga, Oriol Alberto Camargo, Antonio Conde-Gavilan, Cristina Carmona-Medialdea, Claudia Vallejo-Casas, Juan A. Carmona-Asenjo, Elvira Ochoa-Sepulveda, Juan J. Aguera-Morales, Eduardo Delgado-Lista, Javier Katsiki, Niki Lopez-Miranda, José Perez-Jimenez, Francisco Yubero-Serrano, Elena M. Perez-Martínez, Pablo Front Nutr Nutrition INTRODUCTION: Mild cognitive impairment (MCI) can progress to Alzheimer’s disease (AD). When MCI is not properly controlled, the speed of deterioration can dramatically increase. Reduction of oxidative stress/inflammation and the modulation of the gut-brain axis could be new potential therapeutic targets for the prevention and treatment of AD. Consumption of specific nutrients, diets and probiotic supplementation have been evaluated for neurodegenerative disorders. We focus on a detailed description of the study methods and baseline characteristics of a clinical trial aiming to evaluate the efficacy of a combined nutritional intervention, i.e., a Mediterranean diet with probiotics, on cognitive capacity in a population with MCI. METHODS: In this randomized, latin-square crossover, double-blind, and controlled dietary intervention trial (clinicaltrials.gov NCT05029765), 47 MCI patients were randomized to consume three dietary interventions for 24-weeks each: (1) A Mediterranean diet supplemented with probiotics (10(9) colony-forming units of Lactobacillus rhamnosus and Bifidobacterium longum); (2) A Mediterranean diet + placebo; and (3) A Healthy diet according to the World Health Organization (WHO) recommendations. Participants will be evaluated before and after each of the three intervention periods (each 24-weeks, with a total of 72-weeks) for adherence to the assigned diet, blood tests, cognitive performance, gut microbiota analysis and functional neuroimaging studies. RESULTS: Fifty patients, ≥60 years-old and diagnosed with MCI, underwent randomization. A total of 47 patients completed follow-up dietary interventions (57.4% males), with a good glycemic control (HbA1c 5.8 ± 0.1%, fasting glucose and insulin 99.7 ± 3.3 mg/dL and 10.4 ± 0.9 mU/L, respectively), elevated systolic blood pressure (136.9 ± 2.1 mmHg) and increased degree of inflammation (high-sensitivity C-reactive protein, 8.8 ± 0.9 mg/dL). Baseline adherence to the Mediterranean diet was medium (7.5 ± 0.3 points on the score that ranged from 0 to 14 points). CONCLUSION: The results of this clinical study would provide more evidence on the need for dietary therapeutic strategies, for clinical and individual practice, in the management of MCI patients to reduce the risk of AD development. Targeting lifestyle modifications in high-risk populations could prevent substantial cases of cognitive decline. CLINICAL TRIAL REGISTRATION: [ClinicalTrials.gov], identifier [NCT05029765]. Frontiers Media S.A. 2022-12-08 /pmc/articles/PMC9773830/ /pubmed/36570150 http://dx.doi.org/10.3389/fnut.2022.1037842 Text en Copyright © 2022 Cardelo, Corina, Leon-Acuña, Quintana-Navarro, Alcala-Diaz, Rangel-Zuñiga, Camargo, Conde-Gavilan, Carmona-Medialdea, Vallejo-Casas, Carmona-Asenjo, Ochoa-Sepulveda, Aguera-Morales, Delgado-Lista, Katsiki, Lopez-Miranda, Perez-Jimenez, Yubero-Serrano and Perez-Martínez. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Cardelo, Magdalena P.
Corina, Andreea
Leon-Acuña, Ana
Quintana-Navarro, Gracia M.
Alcala-Diaz, Juan F.
Rangel-Zuñiga, Oriol Alberto
Camargo, Antonio
Conde-Gavilan, Cristina
Carmona-Medialdea, Claudia
Vallejo-Casas, Juan A.
Carmona-Asenjo, Elvira
Ochoa-Sepulveda, Juan J.
Aguera-Morales, Eduardo
Delgado-Lista, Javier
Katsiki, Niki
Lopez-Miranda, José
Perez-Jimenez, Francisco
Yubero-Serrano, Elena M.
Perez-Martínez, Pablo
Effect of the Mediterranean diet and probiotic supplementation in the management of mild cognitive impairment: Rationale, methods, and baseline characteristics
title Effect of the Mediterranean diet and probiotic supplementation in the management of mild cognitive impairment: Rationale, methods, and baseline characteristics
title_full Effect of the Mediterranean diet and probiotic supplementation in the management of mild cognitive impairment: Rationale, methods, and baseline characteristics
title_fullStr Effect of the Mediterranean diet and probiotic supplementation in the management of mild cognitive impairment: Rationale, methods, and baseline characteristics
title_full_unstemmed Effect of the Mediterranean diet and probiotic supplementation in the management of mild cognitive impairment: Rationale, methods, and baseline characteristics
title_short Effect of the Mediterranean diet and probiotic supplementation in the management of mild cognitive impairment: Rationale, methods, and baseline characteristics
title_sort effect of the mediterranean diet and probiotic supplementation in the management of mild cognitive impairment: rationale, methods, and baseline characteristics
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773830/
https://www.ncbi.nlm.nih.gov/pubmed/36570150
http://dx.doi.org/10.3389/fnut.2022.1037842
work_keys_str_mv AT cardelomagdalenap effectofthemediterraneandietandprobioticsupplementationinthemanagementofmildcognitiveimpairmentrationalemethodsandbaselinecharacteristics
AT corinaandreea effectofthemediterraneandietandprobioticsupplementationinthemanagementofmildcognitiveimpairmentrationalemethodsandbaselinecharacteristics
AT leonacunaana effectofthemediterraneandietandprobioticsupplementationinthemanagementofmildcognitiveimpairmentrationalemethodsandbaselinecharacteristics
AT quintananavarrograciam effectofthemediterraneandietandprobioticsupplementationinthemanagementofmildcognitiveimpairmentrationalemethodsandbaselinecharacteristics
AT alcaladiazjuanf effectofthemediterraneandietandprobioticsupplementationinthemanagementofmildcognitiveimpairmentrationalemethodsandbaselinecharacteristics
AT rangelzunigaoriolalberto effectofthemediterraneandietandprobioticsupplementationinthemanagementofmildcognitiveimpairmentrationalemethodsandbaselinecharacteristics
AT camargoantonio effectofthemediterraneandietandprobioticsupplementationinthemanagementofmildcognitiveimpairmentrationalemethodsandbaselinecharacteristics
AT condegavilancristina effectofthemediterraneandietandprobioticsupplementationinthemanagementofmildcognitiveimpairmentrationalemethodsandbaselinecharacteristics
AT carmonamedialdeaclaudia effectofthemediterraneandietandprobioticsupplementationinthemanagementofmildcognitiveimpairmentrationalemethodsandbaselinecharacteristics
AT vallejocasasjuana effectofthemediterraneandietandprobioticsupplementationinthemanagementofmildcognitiveimpairmentrationalemethodsandbaselinecharacteristics
AT carmonaasenjoelvira effectofthemediterraneandietandprobioticsupplementationinthemanagementofmildcognitiveimpairmentrationalemethodsandbaselinecharacteristics
AT ochoasepulvedajuanj effectofthemediterraneandietandprobioticsupplementationinthemanagementofmildcognitiveimpairmentrationalemethodsandbaselinecharacteristics
AT agueramoraleseduardo effectofthemediterraneandietandprobioticsupplementationinthemanagementofmildcognitiveimpairmentrationalemethodsandbaselinecharacteristics
AT delgadolistajavier effectofthemediterraneandietandprobioticsupplementationinthemanagementofmildcognitiveimpairmentrationalemethodsandbaselinecharacteristics
AT katsikiniki effectofthemediterraneandietandprobioticsupplementationinthemanagementofmildcognitiveimpairmentrationalemethodsandbaselinecharacteristics
AT lopezmirandajose effectofthemediterraneandietandprobioticsupplementationinthemanagementofmildcognitiveimpairmentrationalemethodsandbaselinecharacteristics
AT perezjimenezfrancisco effectofthemediterraneandietandprobioticsupplementationinthemanagementofmildcognitiveimpairmentrationalemethodsandbaselinecharacteristics
AT yuberoserranoelenam effectofthemediterraneandietandprobioticsupplementationinthemanagementofmildcognitiveimpairmentrationalemethodsandbaselinecharacteristics
AT perezmartinezpablo effectofthemediterraneandietandprobioticsupplementationinthemanagementofmildcognitiveimpairmentrationalemethodsandbaselinecharacteristics