Chronic CD40L blockade is required for long-term cardiac allograft survival with a clinically relevant CTLA4-Ig dosing regimen

INTRODUCTION: In de-novo kidney transplantation, the CTLA4-Ig fusion protein belatacept is associated with improved graft function but also an increased risk of acute rejection compared to calcineurin inhibitor therapy. The combination with a second costimulation blocker could potentially improve ou...

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Detalles Bibliográficos
Autores principales: Unger, Lukas W., Muckenhuber, Moritz, Mahr, Benedikt, Schwarz, Christoph, Pilat, Nina, Granofszky, Nicolas, Regele, Heinz, Wekerle, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773869/
https://www.ncbi.nlm.nih.gov/pubmed/36569922
http://dx.doi.org/10.3389/fimmu.2022.1060576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773869/
https://www.ncbi.nlm.nih.gov/pubmed/36569922
http://dx.doi.org/10.3389/fimmu.2022.1060576

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