Blocking TRPV4 Ameliorates Osteoarthritis by Inhibiting M1 Macrophage Polarization via the ROS/NLRP3 Signaling Pathway

Osteoarthritis (OA) is a low-level inflammatory disease in which synovial macrophage M1 polarization exacerbates the progression of synovitis and OA. Notedly, the ROS (reactive oxygen species) level in macrophages is intimately implicated in macrophage M1 polarization. TRPV4 (transient receptor pote...

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Detalles Bibliográficos
Autores principales: Sun, Heng, Sun, Ziying, Xu, Xingquan, Lv, Zhongyang, Li, Jiawei, Wu, Rui, Fei, Yuxiang, Tan, Guihua, Liu, Zizheng, Liu, Yuan, Shi, Dongquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774183/
https://www.ncbi.nlm.nih.gov/pubmed/36552524
http://dx.doi.org/10.3390/antiox11122315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774183/
https://www.ncbi.nlm.nih.gov/pubmed/36552524
http://dx.doi.org/10.3390/antiox11122315

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