Using Digestion by IdeS Protease to Improve Quantification of Degradants in Monoclonal Antibodies by Non-Reducing Capillary Gel Electrophoresis

[Image: see text] Monoclonal antibodies (mAbs) have become predominant therapeutics by providing highly specific mechanisms of action enabling treatment of complex diseases. However, mAbs themselves are highly complex and require thorough testing and characterization to ensure efficacy and patient s...

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Detalles Bibliográficos
Autores principales: McClain, Andrew, Zhang, Yiting, Yin, Yan, Wang, Qi, Hwang, Lih-Yueh, Gu, Yan, Beckman, Jeff, Ludwig, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774260/
https://www.ncbi.nlm.nih.gov/pubmed/36472948
http://dx.doi.org/10.1021/acs.analchem.2c02630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774260/
https://www.ncbi.nlm.nih.gov/pubmed/36472948
http://dx.doi.org/10.1021/acs.analchem.2c02630

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