A potential antibody repertoire diversification mechanism through tyrosine sulfation for biotherapeutics engineering and production

The diversity of three hypervariable loops in antibody heavy chain and light chain, termed the complementarity-determining regions (CDRs), defines antibody’s binding affinity and specificity owing to the direct contact between the CDRs and antigens. These CDR regions typically contain tyrosine (Tyr)...

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Detalles Bibliográficos
Autores principales: Zhong, Xiaotian, D’Antona, Aaron M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774471/
https://www.ncbi.nlm.nih.gov/pubmed/36569848
http://dx.doi.org/10.3389/fimmu.2022.1072702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774471/
https://www.ncbi.nlm.nih.gov/pubmed/36569848
http://dx.doi.org/10.3389/fimmu.2022.1072702

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