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A potential antibody repertoire diversification mechanism through tyrosine sulfation for biotherapeutics engineering and production
The diversity of three hypervariable loops in antibody heavy chain and light chain, termed the complementarity-determining regions (CDRs), defines antibody’s binding affinity and specificity owing to the direct contact between the CDRs and antigens. These CDR regions typically contain tyrosine (Tyr)...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774471/ https://www.ncbi.nlm.nih.gov/pubmed/36569848 http://dx.doi.org/10.3389/fimmu.2022.1072702 |