Sesamol Attenuates Renal Inflammation and Arrests Reactive-Oxygen-Species-Mediated IL-1β Secretion via the HO-1-Induced Inhibition of the IKKα/NFκB Pathway In Vivo and In Vitro

Chronic nephritis leads to irreversible renal fibrosis, ultimately leading to chronic kidney disease (CKD) and death. Macrophage infiltration and interleukin 1β (IL-1β) upregulation are involved in inflammation-mediated renal fibrosis and CKD. Sesamol (SM), which is extracted from sesame seeds, has...

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Detalles Bibliográficos
Autores principales: Tseng, Kuo-Feng, Tsai, Ping-Hsuan, Wang, Jie-Sian, Chen, Fang-Yu, Shen, Ming-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774643/
https://www.ncbi.nlm.nih.gov/pubmed/36552668
http://dx.doi.org/10.3390/antiox11122461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774643/
https://www.ncbi.nlm.nih.gov/pubmed/36552668
http://dx.doi.org/10.3390/antiox11122461

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