Dexmedetomidine Attenuates Lipopolysaccharide-Induced Sympathetic Activation and Sepsis via Suppressing Superoxide Signaling in Paraventricular Nucleus

Sympathetic overactivity contributes to the pathogenesis of sepsis. The selective α2-adrenergic receptor agonist dexmedetomidine (DEX) is widely used for perioperative sedation and analgesia. We aimed to determine the central roles and mechanisms of DEX in attenuating sympathetic activity and inflam...

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Detalles Bibliográficos
Autores principales: Bo, Jin-Hua, Wang, Jing-Xiao, Wang, Xiao-Li, Jiao, Yang, Jiang, Ming, Chen, Jun-Liu, Hao, Wen-Yuan, Chen, Qi, Li, Yue-Hua, Ma, Zheng-Liang, Zhu, Guo-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774688/
https://www.ncbi.nlm.nih.gov/pubmed/36552603
http://dx.doi.org/10.3390/antiox11122395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774688/
https://www.ncbi.nlm.nih.gov/pubmed/36552603
http://dx.doi.org/10.3390/antiox11122395

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