Pharmacological Inhibition of Lysine-Specific Demethylase 1A Reduces Atherosclerotic Lesion Formation in Apolipoprotein E-Deficient Mice by a Mechanism Involving Decreased Oxidative Stress and Inflammation; Potential Implications in Human Atherosclerosis

Dysregulated epigenetic mechanisms promote transcriptomic and phenotypic alterations in cardiovascular diseases. The role of histone methylation-related pathways in atherosclerosis is largely unknown. We hypothesize that lysine-specific demethylase 1A (LSD1/KDM1A) regulates key molecular effectors a...

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Detalles Bibliográficos
Autores principales: Manea, Simona-Adriana, Vlad, Mihaela-Loredana, Lazar, Alexandra-Gela, Muresian, Horia, Simionescu, Maya, Manea, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774905/
https://www.ncbi.nlm.nih.gov/pubmed/36552592
http://dx.doi.org/10.3390/antiox11122382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774905/
https://www.ncbi.nlm.nih.gov/pubmed/36552592
http://dx.doi.org/10.3390/antiox11122382

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