Covalent DNA Binding Is Essential for Gram-Negative Antibacterial Activity of Broad Spectrum Pyrrolobenzodiazepines

It is urgent to find new antibiotic classes against multidrug-resistant bacteria as the rate of discovery of new classes of antibiotics has been very slow in the last 50 years. Recently, pyrrolobenzodiazepines (PBDs) with a C8-linked aliphatic-heterocycle have been identified as a new broad-spectrum...

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Detalles Bibliográficos
Autores principales: Picconi, Pietro, Hind, Charlotte K., Sutton, J. Mark, Rahman, Khondaker Miraz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774941/
https://www.ncbi.nlm.nih.gov/pubmed/36551427
http://dx.doi.org/10.3390/antibiotics11121770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774941/
https://www.ncbi.nlm.nih.gov/pubmed/36551427
http://dx.doi.org/10.3390/antibiotics11121770

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