Evolutionary Diversity of Dus2 Enzymes Reveals Novel Structural and Functional Features among Members of the RNA Dihydrouridine Synthases Family

Dihydrouridine (D) is an abundant modified base found in the tRNAs of most living organisms and was recently detected in eukaryotic mRNAs. This base confers significant conformational plasticity to RNA molecules. The dihydrouridine biosynthetic reaction is catalyzed by a large family of flavoenzymes...

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Detalles Bibliográficos
Autores principales: Lombard, Murielle, Reed, Colbie J., Pecqueur, Ludovic, Faivre, Bruno, Toubdji, Sabrine, Sudol, Claudia, Brégeon, Damien, de Crécy-Lagard, Valérie, Hamdane, Djemel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775027/
https://www.ncbi.nlm.nih.gov/pubmed/36551188
http://dx.doi.org/10.3390/biom12121760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775027/
https://www.ncbi.nlm.nih.gov/pubmed/36551188
http://dx.doi.org/10.3390/biom12121760

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