A Structure-Based Mechanism for the Denaturing Action of Urea, Guanidinium Ion and Thiocyanate Ion

SIMPLE SUMMARY: The detailed characterization of urea binding sites in protein structures shows that urea can establish multiple types of interactions, in line with recent findings reported for guanidinium and thiocyanate, thus confirming that promiscuity is a general property of protein denaturants...

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Detalles Bibliográficos
Autores principales: Paladino, Antonella, Balasco, Nicole, Vitagliano, Luigi, Graziano, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775367/
https://www.ncbi.nlm.nih.gov/pubmed/36552273
http://dx.doi.org/10.3390/biology11121764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775367/
https://www.ncbi.nlm.nih.gov/pubmed/36552273
http://dx.doi.org/10.3390/biology11121764

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