Microbiome Shapes the T Cell Receptor Repertoire among CD4+CD8+ Thymocytes

The microbiome shapes the mature T cell receptor (TCR) repertoire and thereby influences pathogen control. To investigate microbiome influences on T cells at an earlier, immature stage, we compared single-cell TCR transcript sequences between CD4+CD8+ (double-positive) thymocytes from gnotobiotic [E...

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Detalles Bibliográficos
Autores principales: Surman, Sherri L., Crawford, Jeremy, Dash, Pradyot, Tonkonogy, Susan L., Thomas, Paul G., Hurwitz, Julia L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775422/
https://www.ncbi.nlm.nih.gov/pubmed/36551771
http://dx.doi.org/10.3390/biomedicines10123015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775422/
https://www.ncbi.nlm.nih.gov/pubmed/36551771
http://dx.doi.org/10.3390/biomedicines10123015

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