Cargando…

The Association of CD8+ Cytotoxic T Cells and Granzyme B+ Lymphocytes with Immunosuppressive Factors, Tumor Stage and Prognosis in Cutaneous Melanoma

The immunosuppressive tumor microenvironment (TME) consists of suppressive cells producing a variety of immunomodulatory proteins, such as programmed death ligand 1 (PD-L1) and indoleamine-2,3-dioxygenase (IDO). Although granzyme B (GrB) is known to convey the cytolytic activities of CD8+ cytotoxic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Salmi, Satu, Hälinen, Kaisla, Lin, Anton, Suikkanen, Sanna, Jokelainen, Otto, Rahunen, Eija, Siiskonen, Hanna, Pasonen-Seppänen, Sanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775436/ https://www.ncbi.nlm.nih.gov/pubmed/36551965 http://dx.doi.org/10.3390/biomedicines10123209

Ejemplares similares

The Impact of Hyaluronan on Tumor Progression in Cutaneous Melanoma
por: Takabe, Piia, et al.
Publicado: (2022)

The number and localization of CD68+ and CD163+ macrophages in different stages of cutaneous melanoma
por: Salmi, Satu, et al.
Publicado: (2019)

Inverse expression of hyaluronidase 2 and hyaluronan synthases 1–3 is associated with reduced hyaluronan content in malignant cutaneous melanoma
por: Hanna, Siiskonen, et al.
Publicado: (2013)

The role of FoxP3+ regulatory T cells and IDO+ immune and tumor cells in malignant melanoma – an immunohistochemical study
por: Salmi, Satu, et al.
Publicado: (2021)

Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma
por: Poukka, Mari, et al.
Publicado: (2016)

Hyaluronan Synthase 1: A Mysterious Enzyme with Unexpected Functions
por: Siiskonen, Hanna, et al.
Publicado: (2015)

A practical prognostic peripheral blood-based risk model for the evaluation of the likelihood of a response and survival of metastatic cancer patients treated with immune checkpoint inhibitors
por: Tiainen, Satu, et al.
Publicado: (2023)

Metformin decreases hyaluronan synthesis by vascular smooth muscle cells
por: Sainio, Annele, et al.
Publicado: (2020)

Granzyme B; the chalk-mark of a cytotoxic lymphocyte
por: Waterhouse, Nigel J, et al.
Publicado: (2004)

Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas
por: Valkonen, Mari, et al.
Publicado: (2018)

Mechanisms of local immunosuppression in cutaneous melanoma
por: Polak, M E, et al.
Publicado: (2007)

Granzymes: The Molecular Executors of Immune-Mediated Cytotoxicity
por: Hay, Zachary L. Z., et al.
Publicado: (2022)

HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells
por: Arasu, Uma Thanigai, et al.
Publicado: (2019)

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes
Publicado: (1991)

Irradiation Alters the Expression of MUC1, CD44 and Hyaluronan in Oral Mucosal Epithelium
por: Kashyap, Bina, et al.
Publicado: (2022)

A Genetically Encoded Dark-to-Bright Biosensor for Visualisation of Granzyme-Mediated Cytotoxicity
por: Bednar, Christopher, et al.
Publicado: (2023)

Mast cell chymase is in contact with melanoma cells in vivo and it detaches melanoma cells from the substratum in vitro
por: Siiskonen, Hanna, et al.
Publicado: (2022)

Fish Granzyme A Shows a Greater Role Than Granzyme B in Fish Innate Cell-Mediated Cytotoxicity
por: Chaves-Pozo, Elena, et al.
Publicado: (2019)

Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A
Publicado: (1989)

Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis
por: Mellor-Heineke, Sabine, et al.
Publicado: (2013)

Cytotoxic Lymphocytes Target HIV-1 Gag Through Granzyme M-Mediated Cleavage
por: Saccon, Elisa, et al.
Publicado: (2021)

Future temperature and salinity do not exert selection pressure on cyst germination of a toxic phytoplankton species
por: Jerney, Jacqueline, et al.
Publicado: (2019)

Granzyme family acts as a predict biomarker in cutaneous melanoma and indicates more benefit from anti-PD-1 immunotherapy
por: Wu, Xia, et al.
Publicado: (2021)

A Less Saline Baltic Sea Promotes Cyanobacterial Growth, Hampers Intracellular Microcystin Production, and Leads to Strain-Specific Differences in Allelopathy
por: Brutemark, Andreas, et al.
Publicado: (2015)

Limited evidence for common interannual trends in Baltic Sea summer phytoplankton biomass
por: Griffiths, Jennifer R., et al.
Publicado: (2020)

Interaction Networks Converging on Immunosuppressive Roles of Granzyme B: Special Niches Within the Tumor Microenvironment
por: Wang, Weinan, et al.
Publicado: (2021)

Phytoplankton Morpho-Functional Trait Variability along Coastal Environmental Gradients
por: Lehtinen, Sirpa, et al.
Publicado: (2021)

USP35 is a Potential Immunosuppressive Factor in Skin Cutaneous Melanoma
por: Zhang, Qian, et al.
Publicado: (2022)

Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse
por: Chitirala, Praneeth, et al.
Publicado: (2020)

The target cell nucleus is not required for cell-mediated granzyme- or Fas-based cytotoxicity
Publicado: (1995)

Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria
por: Kaminski, Lea-Christina, et al.
Publicado: (2019)

NK cells switch from granzyme B to death receptor–mediated cytotoxicity during serial killing
por: Prager, Isabel, et al.
Publicado: (2019)

Generalist Life Cycle Aids Persistence of Alexandrium ostenfeldii (Dinophyceae) in Seasonal Coastal Habitats of the Baltic Sea
por: Jerney, Jacqueline, et al.
Publicado: (2019)

Dasatinib promotes Th1-type responses in granzyme B expressing T-cells
por: Kreutzman, Anna, et al.
Publicado: (2014)

High regional mortality due to malignant melanoma in Eastern Finland may be explained by the increase in aggressive melanoma types
por: Suhonen, Ville, et al.
Publicado: (2021)

Assessment of cytotoxic T-lymphocyte phenotype using the specific markers granzyme B and TIA-1 in cervical neoplastic lesions.
por: Bontkes, H. J., et al.
Publicado: (1997)

Inhibitory Effect of Zinc on Colorectal Cancer by Granzyme B Transcriptional Regulation in Cytotoxic T Cells
por: Nakagawa, Naoya, et al.
Publicado: (2023)

Faster cytotoxicity with age: Increased perforin and granzyme levels in cytotoxic CD8 (+) T cells boost cancer cell elimination
por: Zöphel, Dorina, et al.
Publicado: (2022)

Constitutive activation of WASp leads to abnormal cytotoxic cells with increased granzyme B and degranulation response to target cells
por: Kritikou, Joanna S., et al.
Publicado: (2021)

G6PD functions as a metabolic checkpoint to regulate granzyme B expression in tumor-specific cytotoxic T lymphocytes
por: Lu, Chunwan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qpen2l5qgn96f1acul2qrpcp4q