Anticancer Activity of Thiophene Carboxamide Derivatives as CA-4 Biomimetics: Synthesis, Biological Potency, 3D Spheroid Model, and Molecular Dynamics Simulation

The present study aimed to synthesize thiophene carboxamide derivatives, which are considered biomimetics of the anticancer medication Combretastatin A-4 (CA-4), and compare the similarity in the polar surface area (PSA) between the novel series and CA-4. Our results showed that the PSA of the most...

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Detalles Bibliográficos
Autores principales: Hawash, Mohammed, Qaoud, Mohammed T., Jaradat, Nidal, Abdallah, Samer, Issa, Shahd, Adnan, Nawal, Hoshya, Marah, Sobuh, Shorooq, Hawash, Zafer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775471/
https://www.ncbi.nlm.nih.gov/pubmed/36546947
http://dx.doi.org/10.3390/biomimetics7040247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775471/
https://www.ncbi.nlm.nih.gov/pubmed/36546947
http://dx.doi.org/10.3390/biomimetics7040247

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