Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer

Previously, we reported that MTH1 inhibitors TH588 and TH1579 selectively induce oxidative damage and kill Ras-expressing or -transforming cancer cells, as compared to non-transforming immortalized or primary cells. While this explains the impressive anti-cancer properties of the compounds, the mole...

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Detalles Bibliográficos
Autores principales: Henriksson, Sofia, Calderón-Montaño, José Manuel, Solvie, Daniel, Warpman Berglund, Ulrika, Helleday, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775511/
https://www.ncbi.nlm.nih.gov/pubmed/36551206
http://dx.doi.org/10.3390/biom12121777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775511/
https://www.ncbi.nlm.nih.gov/pubmed/36551206
http://dx.doi.org/10.3390/biom12121777

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