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New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common type of dementia, but its pathogenesis is not fully understood, and effective drugs to treat or reverse the progression of the disease are lacking. Long noncoding RNAs (lncRNAs) are abnormally expressed and deregulated in AD and are closely related to the...

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Autores principales: Hao, Yitong, Xie, Bo, Fu, Xiaoshu, Xu, Rong, Yang, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775548/
https://www.ncbi.nlm.nih.gov/pubmed/36551230
http://dx.doi.org/10.3390/biom12121802
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author Hao, Yitong
Xie, Bo
Fu, Xiaoshu
Xu, Rong
Yang, Yu
author_facet Hao, Yitong
Xie, Bo
Fu, Xiaoshu
Xu, Rong
Yang, Yu
author_sort Hao, Yitong
collection PubMed
description Alzheimer’s disease (AD) is the most common type of dementia, but its pathogenesis is not fully understood, and effective drugs to treat or reverse the progression of the disease are lacking. Long noncoding RNAs (lncRNAs) are abnormally expressed and deregulated in AD and are closely related to the occurrence and development of AD. In addition, the high tissue specificity and spatiotemporal specificity make lncRNAs particularly attractive as diagnostic biomarkers and specific therapeutic targets. Therefore, an in-depth understanding of the regulatory mechanisms of lncRNAs in AD is essential for developing new treatment strategies. In this review, we discuss the unique regulatory functions of lncRNAs in AD, ranging from Aβ production to clearance, with a focus on their interaction with critical molecules. Additionally, we highlight the advantages and challenges of using lncRNAs as biomarkers for diagnosis or therapeutic targets in AD and present future perspectives in clinical practice.
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spelling pubmed-97755482022-12-23 New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer’s Disease Hao, Yitong Xie, Bo Fu, Xiaoshu Xu, Rong Yang, Yu Biomolecules Review Alzheimer’s disease (AD) is the most common type of dementia, but its pathogenesis is not fully understood, and effective drugs to treat or reverse the progression of the disease are lacking. Long noncoding RNAs (lncRNAs) are abnormally expressed and deregulated in AD and are closely related to the occurrence and development of AD. In addition, the high tissue specificity and spatiotemporal specificity make lncRNAs particularly attractive as diagnostic biomarkers and specific therapeutic targets. Therefore, an in-depth understanding of the regulatory mechanisms of lncRNAs in AD is essential for developing new treatment strategies. In this review, we discuss the unique regulatory functions of lncRNAs in AD, ranging from Aβ production to clearance, with a focus on their interaction with critical molecules. Additionally, we highlight the advantages and challenges of using lncRNAs as biomarkers for diagnosis or therapeutic targets in AD and present future perspectives in clinical practice. MDPI 2022-12-02 /pmc/articles/PMC9775548/ /pubmed/36551230 http://dx.doi.org/10.3390/biom12121802 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hao, Yitong
Xie, Bo
Fu, Xiaoshu
Xu, Rong
Yang, Yu
New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer’s Disease
title New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer’s Disease
title_full New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer’s Disease
title_fullStr New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer’s Disease
title_full_unstemmed New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer’s Disease
title_short New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer’s Disease
title_sort new insights into lncrnas in aβ cascade hypothesis of alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775548/
https://www.ncbi.nlm.nih.gov/pubmed/36551230
http://dx.doi.org/10.3390/biom12121802
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