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New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common type of dementia, but its pathogenesis is not fully understood, and effective drugs to treat or reverse the progression of the disease are lacking. Long noncoding RNAs (lncRNAs) are abnormally expressed and deregulated in AD and are closely related to the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775548/ https://www.ncbi.nlm.nih.gov/pubmed/36551230 http://dx.doi.org/10.3390/biom12121802 |
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author | Hao, Yitong Xie, Bo Fu, Xiaoshu Xu, Rong Yang, Yu |
author_facet | Hao, Yitong Xie, Bo Fu, Xiaoshu Xu, Rong Yang, Yu |
author_sort | Hao, Yitong |
collection | PubMed |
description | Alzheimer’s disease (AD) is the most common type of dementia, but its pathogenesis is not fully understood, and effective drugs to treat or reverse the progression of the disease are lacking. Long noncoding RNAs (lncRNAs) are abnormally expressed and deregulated in AD and are closely related to the occurrence and development of AD. In addition, the high tissue specificity and spatiotemporal specificity make lncRNAs particularly attractive as diagnostic biomarkers and specific therapeutic targets. Therefore, an in-depth understanding of the regulatory mechanisms of lncRNAs in AD is essential for developing new treatment strategies. In this review, we discuss the unique regulatory functions of lncRNAs in AD, ranging from Aβ production to clearance, with a focus on their interaction with critical molecules. Additionally, we highlight the advantages and challenges of using lncRNAs as biomarkers for diagnosis or therapeutic targets in AD and present future perspectives in clinical practice. |
format | Online Article Text |
id | pubmed-9775548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97755482022-12-23 New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer’s Disease Hao, Yitong Xie, Bo Fu, Xiaoshu Xu, Rong Yang, Yu Biomolecules Review Alzheimer’s disease (AD) is the most common type of dementia, but its pathogenesis is not fully understood, and effective drugs to treat or reverse the progression of the disease are lacking. Long noncoding RNAs (lncRNAs) are abnormally expressed and deregulated in AD and are closely related to the occurrence and development of AD. In addition, the high tissue specificity and spatiotemporal specificity make lncRNAs particularly attractive as diagnostic biomarkers and specific therapeutic targets. Therefore, an in-depth understanding of the regulatory mechanisms of lncRNAs in AD is essential for developing new treatment strategies. In this review, we discuss the unique regulatory functions of lncRNAs in AD, ranging from Aβ production to clearance, with a focus on their interaction with critical molecules. Additionally, we highlight the advantages and challenges of using lncRNAs as biomarkers for diagnosis or therapeutic targets in AD and present future perspectives in clinical practice. MDPI 2022-12-02 /pmc/articles/PMC9775548/ /pubmed/36551230 http://dx.doi.org/10.3390/biom12121802 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hao, Yitong Xie, Bo Fu, Xiaoshu Xu, Rong Yang, Yu New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer’s Disease |
title | New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer’s Disease |
title_full | New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer’s Disease |
title_fullStr | New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer’s Disease |
title_full_unstemmed | New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer’s Disease |
title_short | New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer’s Disease |
title_sort | new insights into lncrnas in aβ cascade hypothesis of alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775548/ https://www.ncbi.nlm.nih.gov/pubmed/36551230 http://dx.doi.org/10.3390/biom12121802 |
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