Structure–Activity Relationship of 5-mer Catalytides, GSGYR and RYGSG

We recently discovered JAL-TA9 (YKGSGFRMI), a short hydrolytic peptide that we termed a Catalytide. The catalytic center of JAL-TA9 was modeled using MM2 and MMFF94 parameters and identified as GSGFR. Additionally, a structure–activity relationship study showed that GSGYR cleaved Aβ11-29. Here, we d...

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Detalles Bibliográficos
Autores principales: Nakamura, Rina, Akizawa, Toshifumi, Konishi, Motomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775622/
https://www.ncbi.nlm.nih.gov/pubmed/36551193
http://dx.doi.org/10.3390/biom12121766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775622/
https://www.ncbi.nlm.nih.gov/pubmed/36551193
http://dx.doi.org/10.3390/biom12121766

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