Secretory Leucoprotease Inhibitor (SLPI) Promotes Survival during Acute Pseudomonas aeruginosa Infection by Suppression of Inflammation Rather Than Microbial Killing

Secretory leucoprotease inhibitor (SLPI) has multifaceted functions, including inhibition of protease activity, antimicrobial functions, and anti-inflammatory properties. In this study, we show that SLPI plays a role in controlling pulmonary Pseudomonas aeruginosa infection. Mice lacking SLPI were h...

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Detalles Bibliográficos
Autores principales: Osbourn, Megan, Rodgers, Aoife M., Dubois, Alice V., Small, Donna M., Humphries, Fiachra, Delagic, Nezira, Moynagh, Paul N., Weldon, Sinéad, Taggart, Clifford C., Ingram, Rebecca J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776001/
https://www.ncbi.nlm.nih.gov/pubmed/36551159
http://dx.doi.org/10.3390/biom12121728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776001/
https://www.ncbi.nlm.nih.gov/pubmed/36551159
http://dx.doi.org/10.3390/biom12121728

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