Sialyltransferase Inhibitor Ac(5)3F(ax)Neu5Ac Reverts the Malignant Phenotype of Pancreatic Cancer Cells, and Reduces Tumor Volume and Favors T-Cell Infiltrates in Mice

SIMPLE SUMMARY: An increase of sialic acid in the cancer cells’ surface is a hallmark of tumours, including pancreatic cancer, and it has been related to tumour malignancy and immune suppression. In this work, we have assessed for the first time the potential of the sialyltransferase inhibitor, Ac(5...

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Detalles Bibliográficos
Autores principales: Miró, Laura, López, Júlia, Guerrero, Pedro E., Martínez-Bosch, Neus, Manero-Rupérez, Noemí, Moreno, Mireia, Ortiz, M. Rosa, Llop, Esther, Navarro, Pilar, Peracaula, Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776040/
https://www.ncbi.nlm.nih.gov/pubmed/36551619
http://dx.doi.org/10.3390/cancers14246133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776040/
https://www.ncbi.nlm.nih.gov/pubmed/36551619
http://dx.doi.org/10.3390/cancers14246133

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