Reliable and Fast Genotyping Protocol for Galactosylceramidase (Galc) in the Twitcher (Twi) Mouse

Twitcher (Twi) is a neurological Krabbe disease (KD, or globoid cell leukodystrophy) spontaneous mutant line in mice. The genome of the Twi mouse presents a single nucleotide polymorphism (SNP), leading to an enzymatically inactive galactosylceramidase (Galc) protein that causes KD. In this context,...

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Detalles Bibliográficos
Autores principales: Carpi, Sara, Del Grosso, Ambra, De Sarlo, Miriam, Colagiorgio, Laura, Scaccini, Luca, Tonazzini, Ilaria, Parlanti, Gabriele, Cecchini, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776230/
https://www.ncbi.nlm.nih.gov/pubmed/36551902
http://dx.doi.org/10.3390/biomedicines10123146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776230/
https://www.ncbi.nlm.nih.gov/pubmed/36551902
http://dx.doi.org/10.3390/biomedicines10123146

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