Prolonged Longitudinal Transcutaneous Auricular Vagus Nerve Stimulation Effect on Striatal Functional Connectivity in Patients with Major Depressive Disorder

Background: Transcutaneous auricular vagus nerve stimulation (taVNS) is effective for treating major depressive disorder (MDD). We aimed to explore the modulating effect of prolonged longitudinal taVNS on the striatal subregions’ functional connectivity (FC) in MDD patients. Methods: Sixteen MDD pat...

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Autores principales: Zhang, Shuai, He, Jia-Kai, Zhong, Gang-Liang, Wang, Yu, Zhao, Ya-Nan, Wang, Lei, Li, Shao-Yuan, Xiao, Xue, Yang, Zheng-Yi, Zhao, Bin, Zhang, Jin-Ling, Jiang, Tian-Zi, Fang, Ji-Liang, Rong, Pei-Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776392/
https://www.ncbi.nlm.nih.gov/pubmed/36552189
http://dx.doi.org/10.3390/brainsci12121730
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author Zhang, Shuai
He, Jia-Kai
Zhong, Gang-Liang
Wang, Yu
Zhao, Ya-Nan
Wang, Lei
Li, Shao-Yuan
Xiao, Xue
Yang, Zheng-Yi
Zhao, Bin
Zhang, Jin-Ling
Jiang, Tian-Zi
Fang, Ji-Liang
Rong, Pei-Jing
author_facet Zhang, Shuai
He, Jia-Kai
Zhong, Gang-Liang
Wang, Yu
Zhao, Ya-Nan
Wang, Lei
Li, Shao-Yuan
Xiao, Xue
Yang, Zheng-Yi
Zhao, Bin
Zhang, Jin-Ling
Jiang, Tian-Zi
Fang, Ji-Liang
Rong, Pei-Jing
author_sort Zhang, Shuai
collection PubMed
description Background: Transcutaneous auricular vagus nerve stimulation (taVNS) is effective for treating major depressive disorder (MDD). We aimed to explore the modulating effect of prolonged longitudinal taVNS on the striatal subregions’ functional connectivity (FC) in MDD patients. Methods: Sixteen MDD patients were enrolled and treated with taVNS for 8 weeks. Sixteen healthy control subjects (HCs) were recruited without intervention. The resting-state FC (rsFC) based on striatal subregion seed points and the Hamilton Depression Scale (HAMD) were evaluated in the MDD patients and HCs at baseline and after 8 weeks. A two-way ANCOVA test was performed on each rsFC metric to obtain the (group-by-time) interactions. Results: The rsFC values between the left ventral caudate (vCa) and right ventral prefrontal cortex (vPFC), and between the right nucleus accumbens (NAc) and right dorsal medial prefrontal cortex (dmPFC) and ventrolateral prefrontal cortex (vlPFC) are lower in the MDD patients compared to the HCs at baseline, and increase following taVNS; the rsFC values between the left vCa and right, superior occipital gyrus (SOG), and between the left dorsal caudate (dCa) and right cuneus are higher in MDD patients and decrease following taVNS. Conclusions: Prolonged longitudinal taVNS can modulate the striatum rsFC with the prefrontal cortex, occipital cortex, temporal cortex, and intra-striatum, and these changes partly underlie any symptomatic improvements. The results indicate that prolonged longitudinal taVNS may produce beneficial treatment effects by modulating the cortical striatum circuitry in patients with MDD.
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spelling pubmed-97763922022-12-23 Prolonged Longitudinal Transcutaneous Auricular Vagus Nerve Stimulation Effect on Striatal Functional Connectivity in Patients with Major Depressive Disorder Zhang, Shuai He, Jia-Kai Zhong, Gang-Liang Wang, Yu Zhao, Ya-Nan Wang, Lei Li, Shao-Yuan Xiao, Xue Yang, Zheng-Yi Zhao, Bin Zhang, Jin-Ling Jiang, Tian-Zi Fang, Ji-Liang Rong, Pei-Jing Brain Sci Article Background: Transcutaneous auricular vagus nerve stimulation (taVNS) is effective for treating major depressive disorder (MDD). We aimed to explore the modulating effect of prolonged longitudinal taVNS on the striatal subregions’ functional connectivity (FC) in MDD patients. Methods: Sixteen MDD patients were enrolled and treated with taVNS for 8 weeks. Sixteen healthy control subjects (HCs) were recruited without intervention. The resting-state FC (rsFC) based on striatal subregion seed points and the Hamilton Depression Scale (HAMD) were evaluated in the MDD patients and HCs at baseline and after 8 weeks. A two-way ANCOVA test was performed on each rsFC metric to obtain the (group-by-time) interactions. Results: The rsFC values between the left ventral caudate (vCa) and right ventral prefrontal cortex (vPFC), and between the right nucleus accumbens (NAc) and right dorsal medial prefrontal cortex (dmPFC) and ventrolateral prefrontal cortex (vlPFC) are lower in the MDD patients compared to the HCs at baseline, and increase following taVNS; the rsFC values between the left vCa and right, superior occipital gyrus (SOG), and between the left dorsal caudate (dCa) and right cuneus are higher in MDD patients and decrease following taVNS. Conclusions: Prolonged longitudinal taVNS can modulate the striatum rsFC with the prefrontal cortex, occipital cortex, temporal cortex, and intra-striatum, and these changes partly underlie any symptomatic improvements. The results indicate that prolonged longitudinal taVNS may produce beneficial treatment effects by modulating the cortical striatum circuitry in patients with MDD. MDPI 2022-12-17 /pmc/articles/PMC9776392/ /pubmed/36552189 http://dx.doi.org/10.3390/brainsci12121730 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Shuai
He, Jia-Kai
Zhong, Gang-Liang
Wang, Yu
Zhao, Ya-Nan
Wang, Lei
Li, Shao-Yuan
Xiao, Xue
Yang, Zheng-Yi
Zhao, Bin
Zhang, Jin-Ling
Jiang, Tian-Zi
Fang, Ji-Liang
Rong, Pei-Jing
Prolonged Longitudinal Transcutaneous Auricular Vagus Nerve Stimulation Effect on Striatal Functional Connectivity in Patients with Major Depressive Disorder
title Prolonged Longitudinal Transcutaneous Auricular Vagus Nerve Stimulation Effect on Striatal Functional Connectivity in Patients with Major Depressive Disorder
title_full Prolonged Longitudinal Transcutaneous Auricular Vagus Nerve Stimulation Effect on Striatal Functional Connectivity in Patients with Major Depressive Disorder
title_fullStr Prolonged Longitudinal Transcutaneous Auricular Vagus Nerve Stimulation Effect on Striatal Functional Connectivity in Patients with Major Depressive Disorder
title_full_unstemmed Prolonged Longitudinal Transcutaneous Auricular Vagus Nerve Stimulation Effect on Striatal Functional Connectivity in Patients with Major Depressive Disorder
title_short Prolonged Longitudinal Transcutaneous Auricular Vagus Nerve Stimulation Effect on Striatal Functional Connectivity in Patients with Major Depressive Disorder
title_sort prolonged longitudinal transcutaneous auricular vagus nerve stimulation effect on striatal functional connectivity in patients with major depressive disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776392/
https://www.ncbi.nlm.nih.gov/pubmed/36552189
http://dx.doi.org/10.3390/brainsci12121730
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