Gain- and Loss-of-Function CFTR Alleles Are Associated with COVID-19 Clinical Outcomes

Carriers of single pathogenic variants of the CFTR (cystic fibrosis transmembrane conductance regulator) gene have a higher risk of severe COVID-19 and 14-day death. The machine learning post-Mendelian model pinpointed CFTR as a bidirectional modulator of COVID-19 outcomes. Here, we demonstrate that...

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Detalles Bibliográficos
Autores principales: Baldassarri, Margherita, Zguro, Kristina, Tomati, Valeria, Pastorino, Cristina, Fava, Francesca, Croci, Susanna, Bruttini, Mirella, Picchiotti, Nicola, Furini, Simone, Pedemonte, Nicoletta, Gabbi, Chiara, Renieri, Alessandra, Fallerini, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776607/
https://www.ncbi.nlm.nih.gov/pubmed/36552859
http://dx.doi.org/10.3390/cells11244096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776607/
https://www.ncbi.nlm.nih.gov/pubmed/36552859
http://dx.doi.org/10.3390/cells11244096

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