Pharmacological Profile of MP-101, a Novel Non-racemic Mixture of R- and S-dimiracetam with Increased Potency in Rat Models of Cognition, Depression and Neuropathic Pain

The racemic mixture dimiracetam negatively modulates NMDA-induced glutamate release in rat spinal cord synaptosomal preparations and is orally effective in models of neuropathic pain. In this study, we compared the effects of dimiracetam, its R- or S-enantiomers, and the R:S 3:1 non-racemic mixture...

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Detalles Bibliográficos
Autores principales: Bonifacino, Tiziana, Micheli, Laura, Torazza, Carola, Ghelardini, Carla, Farina, Carlo, Bonanno, Giambattista, Milanese, Marco, Di Cesare Mannelli, Lorenzo, Scherz, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776800/
https://www.ncbi.nlm.nih.gov/pubmed/36552791
http://dx.doi.org/10.3390/cells11244027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776800/
https://www.ncbi.nlm.nih.gov/pubmed/36552791
http://dx.doi.org/10.3390/cells11244027

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