Cargando…

AP-2δ Is the Most Relevant Target of AP-2 Family-Focused Cancer Therapy and Affects Genome Organization

Formerly hailed as “undruggable” proteins, transcription factors (TFs) are now under investigation for targeted therapy. In cancer, this may alter, inter alia, immune evasion or replicative immortality, which are implicated in genome organization, a process that accompanies multi-step tumorigenesis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kołat, Damian, Zhao, Lin-Yong, Kciuk, Mateusz, Płuciennik, Elżbieta, Kałuzińska-Kołat, Żaneta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776946/ https://www.ncbi.nlm.nih.gov/pubmed/36552887 http://dx.doi.org/10.3390/cells11244124

Ejemplares similares

The biological characteristics of transcription factors AP-2α and AP-2γ and their importance in various types of cancers
por: Kołat, Damian, et al.
Publicado: (2019)

Functional genomics of AP-2α and AP-2γ in cancers: in silico study
por: Kołat, Damian, et al.
Publicado: (2020)

Determination of WWOX Function in Modulating Cellular Pathways Activated by AP-2α and AP-2γ Transcription Factors in Bladder Cancer
por: Kołat, Damian, et al.
Publicado: (2022)

WWOX Loses the Ability to Regulate Oncogenic AP-2γ and Synergizes with Tumor Suppressor AP-2α in High-Grade Bladder Cancer
por: Kołat, Damian, et al.
Publicado: (2021)

Prognostic significance of AP-2α/γ targets as cancer therapeutics
por: Kołat, Damian, et al.
Publicado: (2022)

In vitro and in silico assessment of the effect of WWOX expression on invasiveness pathways associated with AP-2 transcription factors in bladder cancer
por: Kałuzińska, Żaneta, et al.
Publicado: (2021)

The artificial oxygen carrier erythrocruorin—characteristics and potential significance in medicine
por: Kruczkowska, Weronika, et al.
Publicado: (2023)

PLEK2, RRM2, GCSH: A Novel WWOX-Dependent Biomarker Triad of Glioblastoma at the Crossroads of Cytoskeleton Reorganization and Metabolism Alterations
por: Kałuzińska, Żaneta, et al.
Publicado: (2021)

Fragile Gene WWOX Guides TFAP2A/TFAP2C-Dependent Actions Against Tumor Progression in Grade II Bladder Cancer
por: Kołat, Damian, et al.
Publicado: (2021)

Corrigendum: Fragile Gene WWOX Guides TFAP2A/TFAP2C-Dependent Actions Against Tumor Progression in Grade II Bladder Cancer
por: Kołat, Damian, et al.
Publicado: (2021)

Pyroptosis-related signatures in bladder cancer prognosis and treatment—are we there yet?
por: Kołat, Damian, et al.
Publicado: (2022)

Antineoplastic Nature of WWOX in Glioblastoma Is Mainly a Consequence of Reduced Cell Viability and Invasion
por: Kałuzińska-Kołat, Żaneta, et al.
Publicado: (2023)

Delineating the glioblastoma stemness by genes involved in cytoskeletal rearrangements and metabolic alterations
por: Kałuzińska-Kołat, Żaneta, et al.
Publicado: (2023)

Molecular landscapes of glioblastoma cell lines revealed a group of patients that do not benefit from WWOX tumor suppressor expression
por: Kałuzińska-Kołat, Żaneta, et al.
Publicado: (2023)

LINC01137/miR-186-5p/WWOX: a novel axis identified from WWOX-related RNA interactome in bladder cancer
por: Kołat, Damian, et al.
Publicado: (2023)

PD-1/PD-L1 and DNA Damage Response in Cancer
por: Kciuk, Mateusz, et al.
Publicado: (2023)

Doxorubicin—An Agent with Multiple Mechanisms of Anticancer Activity
por: Kciuk, Mateusz, et al.
Publicado: (2023)

Substances of Natural Origin in Medicine: Plants vs. Cancer
por: Gielecińska, Adrianna, et al.
Publicado: (2023)

MicroRNAs: Their Role in Metastasis, Angiogenesis, and the Potential for Biomarker Utility in Bladder Carcinomas
por: Hammouz, Raneem Y., et al.
Publicado: (2021)

Do COVID-19 Vaccinations Affect the Most Common Post-COVID Symptoms? Initial Data from the STOP-COVID Register–12-Month Follow-Up
por: Babicki, Mateusz, et al.
Publicado: (2023)

Do selected lifestyle parameters affect the severity and symptoms of COVID-19 among elderly patients? The retrospective evaluation of individuals from the STOP-COVID registry of the PoLoCOV study
por: Kapusta, Joanna, et al.
Publicado: (2023)

Long-COVID Clinical Features and Risk Factors: A Retrospective Analysis of Patients from the STOP-COVID Registry of the PoLoCOV Study
por: Chudzik, Michał, et al.
Publicado: (2022)

Do the Successive Waves of SARS-CoV-2, Vaccination Status and Place of Infection Influence the Clinical Picture and COVID-19 Severity among Patients with Persistent Clinical Symptoms? The Retrospective Study of Patients from the STOP-COVID Registry of the PoLoCOV-Study
por: Chudzik, Michał, et al.
Publicado: (2022)

Exosomes as carriers transporting long non-coding RNAs: Molecular characteristics and their function in cancer
por: Kołat, Damian, et al.
Publicado: (2019)

Carboxymethyl Chitosan Hydrogels for Effective Wound Healing—An Animal Study
por: Kłosiński, Karol Kamil, et al.
Publicado: (2023)

Does the severity of the course of COVID-19 in pts without hospitalization and no history of cardiovascular disease affect of cardiac arrhythmias
por: Chudzik, M, et al.
Publicado: (2023)

Biocompatibility and Mechanical Properties of Carboxymethyl Chitosan Hydrogels
por: Kłosiński, Karol K., et al.
Publicado: (2022)

Generation of a new mouse model of glaucoma characterized by reduced expression of the AP-2β and AP-2δ proteins
por: Barzago, Maria Monica, et al.
Publicado: (2017)

Whether and what abnormalities we find in ECG records and 24-hour Holter ECG in patients after COVID-19 without hospitalization with cardiac damage
por: Chudzik, M, et al.
Publicado: (2023)

The AP-2 family of transcription factors
por: Eckert, Dawid, et al.
Publicado: (2005)

AP-2δ Is a Crucial Transcriptional Regulator of the Posterior Midbrain
por: Hesse, Katrin, et al.
Publicado: (2011)

Bioinformatic prediction of the AP2/ERF family genes in Eucalyptus grandis: focus on the CBF family
por: Azar, Sahar, et al.
Publicado: (2011)

The Cryptosporidium parvum ApiAP2 gene family: insights into the evolution of apicomplexan AP2 regulatory systems
por: Oberstaller, Jenna, et al.
Publicado: (2014)

AP-2δ Expression Kinetics in Multimodal Networks in the Developing Chicken Midbrain
por: Kettler, Lutz, et al.
Publicado: (2021)

Implementation of the Horizontal Focusing Optics at APS
por: Sajaev, Vadim, et al.
Publicado: (2001)

Genome-Wide Identification of the Target Genes of AP2-O, a Plasmodium AP2-Family Transcription Factor
por: Kaneko, Izumi, et al.
Publicado: (2015)

AP-2 gets demoted
por: Dove, Alan W.
Publicado: (2003)

Differentiation of Zebrafish Melanophores Depends on Transcription Factors AP2 Alpha and AP2 Epsilon
por: Van Otterloo, Eric, et al.
Publicado: (2010)

The Drosophila melanogaster Mutants ap(blot) and ap(Xasta) Affect an Essential apterous Wing Enhancer
por: Bieli, Dimitri, et al.
Publicado: (2015)

Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views
por: Jin, Chen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tkri0otbs1a11gkrqglrt72063