API-2-Induced Cell Migration Is Overcome by Small Molecular Approaches Inhibiting β-Catenin

Frequent mutation of APC (90%) in advanced colorectal cancer (CRC) results in the simultaneous activation of Wnt/β-catenin and AKT signaling pathways, and the current therapeutic limitations of the AKT inhibitors for treating CRC patients are nuclear β-catenin-induced EMT and bypassing apoptosis. In...

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Detalles Bibliográficos
Autores principales: Kim, Yonghyo, Kang, Myoung-Hee, Cho, Yong-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777436/
https://www.ncbi.nlm.nih.gov/pubmed/36547070
http://dx.doi.org/10.3390/cimb44120409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777436/
https://www.ncbi.nlm.nih.gov/pubmed/36547070
http://dx.doi.org/10.3390/cimb44120409

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