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API-2-Induced Cell Migration Is Overcome by Small Molecular Approaches Inhibiting β-Catenin

Frequent mutation of APC (90%) in advanced colorectal cancer (CRC) results in the simultaneous activation of Wnt/β-catenin and AKT signaling pathways, and the current therapeutic limitations of the AKT inhibitors for treating CRC patients are nuclear β-catenin-induced EMT and bypassing apoptosis. In...

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Detalles Bibliográficos
Autores principales:	Kim, Yonghyo, Kang, Myoung-Hee, Cho, Yong-Hee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777436/ https://www.ncbi.nlm.nih.gov/pubmed/36547070 http://dx.doi.org/10.3390/cimb44120409

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