The Role of Nuclear-Encoded Mitochondrial tRNA Charging Enzymes in Human Inherited Disease

Aminoacyl-tRNA synthetases (ARSs) are highly conserved essential enzymes that charge tRNA with cognate amino acids—the first step of protein synthesis. Of the 37 nuclear-encoded human ARS genes, 17 encode enzymes are exclusively targeted to the mitochondria (mt-ARSs). Mutations in nuclear mt-ARS gen...

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Detalles Bibliográficos
Autores principales: Del Greco, Christina, Antonellis, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777667/
https://www.ncbi.nlm.nih.gov/pubmed/36553587
http://dx.doi.org/10.3390/genes13122319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777667/
https://www.ncbi.nlm.nih.gov/pubmed/36553587
http://dx.doi.org/10.3390/genes13122319

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